ūüĒóEnlaces

Concentraci√≥n de receptores con residuos de √°cido si√°lico en gl√°ndula mamaria de vacas lecheras explicar√≠a la alta concentraci√≥n de virus influenza (H5N1) en la leche. Concentra√ß√£o de receptores com res√≠duos de √°cido si√°lico na gl√Ęndula mam√°ria de vacas leiteiras explicaria a alta concentra√ß√£o do v√≠rus influenza (H5N1) no leite. 11 de mayo 2024.

The avian and human influenza A virus receptors sialic acid (SA)-őĪ2,3 and SA-őĪ2,6 are widely expressed in the bovine mammary glandAn outbreak of H5N1 highly pathogenic influenza A virus (HPIAV) has been detected in dairy cows in the United States. Influenza A virus (IAV) is a negative-sense, single-stranded, RNA virus that has not previously been associated with widespread infection in cattle. As such, cattle are an extremely under-studied domestic IAV host species. IAV receptors on host cells are sialic acids (SAs) that are bound to galactose in either an őĪ2,3 or őĪ2,6 linkage. Human IAVs preferentially bind SA-őĪ2,6 (human receptor), whereas avian IAVs have a preference for őĪ2,3 (avian receptor). The avian receptor can further be divided into two receptors: IAVs isolated from chickens generally bind more tightly to SA-őĪ2,3-Gal-ő≤1,4 (chicken receptor), whereas IAVs isolated from duck to SA-őĪ2,3-Gal-ő≤1,3 (duck receptor). We found all receptors were expressed, to a different degree, in the mammary gland, respiratory tract, and cerebrum of beef and/or dairy cattle. The duck and human IAV receptors were widely expressed in the bovine mammary gland, whereas the chicken receptor dominated the respiratory tract. In general, only a low expression of IAV receptors was observed in the neurons of the cerebrum. These results provide a mechanistic rationale for the high levels of H5N1 virus reported in infected bovine milk and show cattle have the potential to act as a mixing vessel for novel IAV generation. Graphical abstract Created with [Biorender.com][1] ![Figure][2]</img> ### Competing Interest Statement The authors have declared no competing interest. [1]: http://Biorender.com [2]: pending:yes

Recientes brotes de influenza en ganado abre cuestionamientos sobre el uso de cama de aves en la alimentación

La reciente aparici√≥n de brotes de influenza aviar en bovinos de Estados Unidos de Am√©rica, abre nuevas perspectivas epidemiol√≥gicas con respecto al uso de desechos originados en la industria av√≠cola. El problema actual es que a√ļn no se ha podido detectar el origen de la infecci√≥n aunque probablemente ello sea mediante contacto con aves. Sin embargo, se debe analizar una pr√°ctica est√°ndar de "reciclaje" empleada por miles de agricultores en muchas partes del mundo, alimentar con desechos y partes de animales al ganado criado para consumo humano (Conocido como cama de aves). Sin embargo, hasta esta fecha no existe evidencia de transmisi√≥n mediante esta v√≠a, pero no se puede descartar. Mas informaci√≥n en: https://phys.org/news/2024-04-avian-flu-outbreak-disturbing.html